Priya Sivaramakrishnan Lab
at the Children’s Hospital of Philadelphia and University of Pennsylvania
The Sivaramakrishnan Lab studies how cell identities are determined during embryonic development.
Research Areas
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Identifying the determinants that regulate transcription rate and mRNA output
How does transcription keep pace with the rapid cell fate decisions that occur in the early C. elegans embryo?
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Establishing the connection between transcription kinetics and mRNA dosage precision
Can we identify mechanisms that help embryonic cells defy the stochasticity of molecular events (noise), allowing for developmental robustness?
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Cell size-dependent control of transcription rates and dosage
Does the size of an embryonic cell set limits on the rate and absolute levels of individual transcribed genes?
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C. elegans as a model to study transcriptional dysregulation and variable expressivity in developmental disorders
What can the humble worm tell us about the molecular basis of transcription-associated developmental disorders?
Lab Culture
The Sivaramakrishnan lab is all about community. We embrace diversity and welcome anyone with a love for science and worms. We want to hear everyone’s ideas—no questions too small or irrelevant.
If you would like to be part of this lab, get in touch with us—let’s talk about how we can work together.
We’re Hiring!
The Priya Sivaramakrishnan Lab opened on 1 January 2024 at the Center for Computational and Genomic Medicine at CHOP and the Department of Pathology and Laboratory Medicine at Penn.
If you are interested in worms and would like to work on any of our lab’s projects, solving the mysteries of cell fate during development, email psiv@pennmedicine.upenn.edu to apply for a position.